Chemical biology analysis of epigenetics in SCLC (B04+)

• Subject Area: Biochemistry ; General Genetics and Functional Genome Biology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 413326622

In the project the Knapp group will generate a comprehensive chemical probe set for the development of new treatment strategies for SCLC. The chemical probe set will comprise more than hundred highly selective comprehensively characterized small molecules that target epigenetic modulators of the epigenetic code. The aim is to identify at least 3 new targets for the development of drugs by these screening experiments, which will be validated using CRISPR/Cas9 deletion studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1399: Mechanisms of drug sensitivity and resistance in small cell lung cancer
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Stefan Knapp