Assembly and biogenesis of respiratory complex III and of related supercomplexes (A05)

• Subject Area: Structural Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

Cellular respiration is accomplished by a sophisticated machinery of membrane-bound, multiprotein and cofactor-bearing respiratory complexes that can form higher-order structures (supercomplexes). Assembly of these complexes is tightly regulated to avoid partially assembled malfunctioning complexes and to adapt the cell to changes in energetic demands. We will provide in-depth structural and mechanistic insight into the coordinated biogenesis of respiratory chain complex III and its related supercomplexes and also analyse the role of the mitochondrial signature lipid cardiolipin in this complex assembly process.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Carola Hunte