Assembly of the T cell receptor signalosomes (A09)

• Subject Area: Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

Stimulation of the T cell receptor (TCR) leads to the activation of T cells. The TCR is a complex macromolecular protein machinery and its subunits undergo structural alterations during the biogenesis process and later upon ligand binding. In this project we want to unravel the molecular constituents that form the self- and foreign-TCR signalosomes by which the T cells distinguish self and foreign antigens based on the antigen binding time.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Wolfgang Schamel