Identification and characterization of MOF interaction and substrate repertoire (B03)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

Histone acetylation is a prominent epigenetic modification playing diverse roles in several cellular processes. MOF (Males absent On the First) is the major lysine acetyl transferase responsible for deposition of histone H4 lysine 16 (H4K16ac). We found that MOF dually localizes to the nucleus and mitochondria. We will study the function of mitochondrial MOF subcomplexes and investigate the consequences of MOF acetylation of mitochondrial proteins on mitochondrial functions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Asifa Akhtar, Ph.D.