Modular assembly of the autophagy machinery in mitophagy and immunity (B10)

• Subject Area: Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

Autophagy is a cellular transport pathway in which cytoplasmic components are targeted for degradation. Defects in autophagy have been associated with several human diseases, including autoimmunity. We aim to investigate the role of the autophagy machineries Atg1 and LRBA and their subcomplexes in the autophagic degradation of mitochondria and analyse the role of LRBA in the crosstalk of mitophagy and immunity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Laura Gámez-Díaz, since 7/2023; Professorin Dr. Claudine Kraft