ncRNA control of multi-protein complex activity (A05)

• Subject Area: Cell Biology ; Cardiology, Angiology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

In the previous funding period, we identified a nuclear encoded lncRNA that is translocated to mitochondria, regulating activity of branched chain amino acid catabolism and thereby controling cardiac hypertrophy. We also detected additional mitochondrially-localised lncRNAs with unknown functions in cardiomyocytes and in smooth muscle cells, whose biochemical and physiological functions will be determined in the next funding period. Furthermore, we will uncover the molecular and physiological functions of lncRNAs, interacting with the INO80 chromatin remodeling complex, which were identified by an in vivo HyperTRIBE approach in the last funding period.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Thomas Braun; Privatdozent Dr. Thomas Böttger