RNA regulatory mechanisms in cardiac metabolism (B07)

• Subject Area: Cardiology, Angiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

We have demonstrated in mouse models a requirement for enhancer-templated RNAs (eRNAs) in cardiac cardiac hypertrophy and heart failure. The proposed project builds on this observation and aims to assess the pathophysiologic relevance of specific functionally validated eRNAs in human disease models (iPS-derived cardiac organoids) and test the therapeutic manipulation of these molecules in mouse models of heart disease. The overarching goal of this project is to identify clinically-relevant eRNA targets for the treatment of human heart disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Jaya Krishnan, Ph.D.