Towards neurobehavioral profiles and models of adaptive stress responses and resilience in individuals with alcohol use disorder (A03)

• Subject Area: Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry ; Biological Psychiatry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 402170461

In the 1st FP, we showed that combined experimental stress- and alcohol cue-exposure significantly interact, resulting in increased perceived stress, cortisol levels, alcohol craving and neural alcohol cue-reactivity in individuals with alcohol use disorder, which was associated with higher real-life alcohol use. In the 2nd FP, we seek to identify neurobehavioral profiles of adaptive stress responses and resilience by employing an intense longitudinal multimodal interventional phenotyping approach incorporating an established experimental stress-induction protocol.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 265: Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Privatdozent Dr. Patrick Bach, since 7/2023; Professor Dr. Falk Kiefer; Professor Dr. Clemens Kirschbaum; Professor Dr.-Ing. Jan Stallkamp, until 6/2023