Components and modulators of inflexible control in human addiction (B01)

• Subject Area: Biological Psychology and Cognitive Neuroscience ; Biological Psychiatry ; Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry ; Human Cognitive and Systems Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 402170461

In the 1st FP, we found that model-based control during sequential decision making predicted better control over real-world drinking behavior in AUD. Further, we developed a motor-sequence learning task to induce habit-like behavior as slips-of-action to examine the habit formation process. Building on those findings our aims in the 2nd FP are: First, to investigate if the development of habit-like behavior and the adjustment of learned responses in AUD is related to a loss of control over alcohol intake in everyday life. Second, we will test the influence of negative emotional states as contextual factor on the use of model-based control in AUD using alcohol rewards.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 265: Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Tanja Endrass; Professor Dr. Florian Schlagenhauf