Project Details
Projekt
Chronic inflammasome activation in post-stroke recovery
Applicants
Professor Dr. Veit Hornung; Professor Dr. Arthur Liesz; Privatdozentin Dr. Antje Schmidt-Pogoda
Subject Area
Molecular and Cellular Neurology and Neuropathology
Molecular Biology and Physiology of Neurons and Glial Cells
Molecular Biology and Physiology of Neurons and Glial Cells
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 405358801
In our collaborative project, we want to understand how inflammasome activation is involved in chronic neuroinflammation after stroke. Expanding on our findings from the first funding period, we want to address now the mechanisms which lead contributing to chronic inflammasome activation and analyze the impact of inflammasome activation on long-range neuronal connectivity. Specifically, we will analyze dysfunctional lipid metabolism as a cause of inflammasome activation in immune and non-immune cells of the brain. We will focus on reorganization of the corticospinal tract after stroke to study the role of inflammasome activation on neuronal plasticity.
DFG Programme
Research Units
