Identifying pathways and factors causing primary focal segmental glomerulosclerosis (B08)

• Subject Area: Nephrology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

Focal segmental glomerulosclerosis (FSGS) is a progressive and devastating glomerular disease and a major glomerular reason for end stage renal disease. We now aim to (1) systematically integrate the multi-omics datasets obtained from all models mentioned above; (2) characterize and validate identified common and novel FSGS pathways and circulating factor(s); and (3) implement a pipeline for systematic drug repurposing. Together, this project will facilitate FSGS pathway and treatment discovery and shall exemplify a generalizable translational glomerular disease strategy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Heads: Professor Dr. Tobias B. Huber; Dr. Anne Katrin Mühlig