Cellular and molecular checkpoints of circuit refinement following traumatic injuries of the CNS (C03)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537

There is to date no therapy that prevents the devastating consequences of traumatic brain and spinal cord injuries. Previous work has shown that neuronal connections can spontaneously remodel after CNS injuries, a process that contributes to functional recovery. Here, we propose that the balance between adaptive and maladaptive neuronal remodeling depends on circuit refinement and is guided by the interplay between neuronal activity and microglia-driven synapse removal. We aim to identify the checkpoints for circuit refinement and reveal whether such checkpoints are maintained between different injury types and locations.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 274: Checkpoints of Central Nervous System Recovery
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Privatdozentin Dr. Florence Bareyre