Struktur-Funktionsbeziehungen und Plastizität im Hippocampus von Nagern
Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Zusammenfassung der Projektergebnisse
The project focused on the cellular mechanisms underlying episodic memory formation. Specifically, the proposed experiments aimed at resolving structure-function relationships (AIM1) and probing plasticity mechanisms (AIM2) of single neurons in the mouse hippocampus. In this project, we identified novel structure-function relationships which contribute to the selective recruitment of hippocampal pyramidal neurons into spatial representations and into memory-related, patterned network activity. To optimally address our experimental questions, we have also established novel opto-juxtacellular technology for targeting, labelling and stimulating single neurons in freely-moving animals and for probing plasticity mechanisms during ethologically-relevant behavioral state fluctuations. In the latter research line, we found that behavioral states are gain-encoded within a dedicated subset of place cells, and modulate hippocampal oscillatory dynamics and plasticity. Additional research lines are currently focusing on complementary aspects of hippocampal coding, namely object- and social-representations in CA2 and the Fasciola Cinera. In summary, the above research has contributed to our understanding of the neural basis of episodic memory by shedding light onto structure-function relationships and plasticity mechanisms of hippocampal neurons during ethologically relevant behavioral states.
Projektbezogene Publikationen (Auswahl)
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Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice. The Journal of Neuroscience, 40(30), 5797-5806.
Ding, Lingjun; Chen, Hongbiao; Diamantaki, Maria; Coletta, Stefano; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons. Science, 377(6613), 1448-1452.
Hodapp, Alexander; Kaiser, Martin E.; Thome, Christian; Ding, Lingjun; Rozov, Andrei; Klumpp, Matthias; Stevens, Nikolas; Stingl, Moritz; Sackmann, Tina; Lehmann, Nadja; Draguhn, Andreas; Burgalossi, Andrea; Engelhardt, Maren & Both, Martin
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Juxtacellular opto-tagging of hippocampal CA1 neurons in freely moving mice. eLife, 11.
Ding, Lingjun; Balsamo, Giuseppe; Chen, Hongbiao; Blanco-Hernandez, Eduardo; Zouridis, Ioannis S.; Naumann, Robert; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Opto-juxtacellular interrogation of neural circuits in freely moving mice. Nature Protocols, 18(8), 2415-2440.
Ding, Lingjun; Balsamo, Giuseppe; Diamantaki, Maria; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus. Hippocampus, 34(10), 528-539.
Zouridis, Ioannis S.; Balsamo, Giuseppe; Preston‐Ferrer, Patricia & Burgalossi, Andrea
