Structure-function relationships and plasticity in the rodent hippocampus
Molecular Biology and Physiology of Neurons and Glial Cells
Final Report Abstract
The project focused on the cellular mechanisms underlying episodic memory formation. Specifically, the proposed experiments aimed at resolving structure-function relationships (AIM1) and probing plasticity mechanisms (AIM2) of single neurons in the mouse hippocampus. In this project, we identified novel structure-function relationships which contribute to the selective recruitment of hippocampal pyramidal neurons into spatial representations and into memory-related, patterned network activity. To optimally address our experimental questions, we have also established novel opto-juxtacellular technology for targeting, labelling and stimulating single neurons in freely-moving animals and for probing plasticity mechanisms during ethologically-relevant behavioral state fluctuations. In the latter research line, we found that behavioral states are gain-encoded within a dedicated subset of place cells, and modulate hippocampal oscillatory dynamics and plasticity. Additional research lines are currently focusing on complementary aspects of hippocampal coding, namely object- and social-representations in CA2 and the Fasciola Cinera. In summary, the above research has contributed to our understanding of the neural basis of episodic memory by shedding light onto structure-function relationships and plasticity mechanisms of hippocampal neurons during ethologically relevant behavioral states.
Publications
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Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice. The Journal of Neuroscience, 40(30), 5797-5806.
Ding, Lingjun; Chen, Hongbiao; Diamantaki, Maria; Coletta, Stefano; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons. Science, 377(6613), 1448-1452.
Hodapp, Alexander; Kaiser, Martin E.; Thome, Christian; Ding, Lingjun; Rozov, Andrei; Klumpp, Matthias; Stevens, Nikolas; Stingl, Moritz; Sackmann, Tina; Lehmann, Nadja; Draguhn, Andreas; Burgalossi, Andrea; Engelhardt, Maren & Both, Martin
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Juxtacellular opto-tagging of hippocampal CA1 neurons in freely moving mice. eLife, 11.
Ding, Lingjun; Balsamo, Giuseppe; Chen, Hongbiao; Blanco-Hernandez, Eduardo; Zouridis, Ioannis S.; Naumann, Robert; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Opto-juxtacellular interrogation of neural circuits in freely moving mice. Nature Protocols, 18(8), 2415-2440.
Ding, Lingjun; Balsamo, Giuseppe; Diamantaki, Maria; Preston-Ferrer, Patricia & Burgalossi, Andrea
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Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus. Hippocampus, 34(10), 528-539.
Zouridis, Ioannis S.; Balsamo, Giuseppe; Preston‐Ferrer, Patricia & Burgalossi, Andrea
