Searching for intracollicular neural substrate and neural pathways involved in paradoxical kinesia in rats
Final Report Abstract
Our main goal is to uncover the neural mechanism underlying paradoxical kinesia, an intriguing phenomenon that enables some akinetic patients with Parkinson’s disease to make quick and accurate movements when exposed to specific auditory or visual stimuli. The bulk of evidences obtained by our group strongly suggest the inferior colliculus (IC) as part of an alternative pathway that, when activated, induces motor improvement and thus paradoxical kinesia. However, the exact identity of this pathway, and how it is activated, is still unknown. The present proposal aimed to further investigate which IC projections are involved in this motor response and which intracollicular neural substrate is activated in order to trigger paradoxical kinesia. For that, optogenetic technique was used to target specifically glutamatergic neurons in the IC and assess the behavioral outcome. Additionally, intracollicular optogenetic modulation was combined with electrophysiological neural recordings in order to monitor simultaneously neural activity both in the vicinity of and distant to the stimulation site.
Publications
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Intracollicular deep brain stimulation of parkinsonian rats ameliorates motor deficits and anxiety. PLoS One. 15(12):e0243438
Ihme H., Schwarting R.K.W. & Melo-Thomas L.
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Cinesia paradoxal, um diálogo entre emoções e controle motor. In: Tostes GJ and Tostes CBS. Psicopatologia: Fenômeno e outras perspectivas.1st ed. Belo Horizonte: Tradição Planalto, 2021. Cap. 7, p. 87-108
Melo-Thomas, L.
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Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress. PLOS ONE, 17(3), e0262728.
de Oliveira, Rodolpho Pereira; de Andrade, José Simões; Spina, Marianna; Chamon, João Vítor; Silva, Paulo Henrique Dias; Werder, Ana Keyla; Ortolani, Daniela; Thomaz, Lucas de Santana Cardoso; Romariz, Simone; Ribeiro, Daniel Araki; Longo, Beatriz Monteiro; Spadari, Regina Célia; Viana, Milena de Barros; Melo-Thomas, Liana; Céspedes, Isabel Cristina & da, Silva Regina Cláudia Barbosa
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Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus. eneuro, 9(4), ENEURO.0076-22.2022.
Melo-Thomas, Liana; Tacken, Lars; Richter, Nicole; de Almeida, Davina; Rapôso, Catarina; de Melo, Silvana Regina; Thomas, Uwe; de Paiva, Yara Bezerra; Medeiros, Priscila; Coimbra, Norberto Cysne & Schwarting, Rainer
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Paradoxical kinesia may no longer be a paradox waiting for 100 years to be unraveled. Reviews in the Neurosciences, 34(7), 775-799.
Melo-Thomas, Liana & Schwarting, Rainer K. W.
