Interrogating CD95 Membrane Protein Complex Formation and its Signalling for Life or Death (A12)

• Subject Area: Biochemistry
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 267205415

The plasma membrane protein "cluster of differentiation 95" (CD95) plays a prominent role in mammalian cell signalling for apoptosis, but recent studies demonstrate its additional role in proliferation. Here, we aim to decipher how different CD95 activity states at the level of the plasma membrane affect signal transduction and the overall cell response. To this end, we interrogate CD95 interaction and complex formation after passive or active stimulation in live cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professorin Dr. Cornelia Monzel