Molecular Principles of Interleukin-6/-11 Classic and Trans-Signalling

• Applicant: Professor Dr. Jürgen Scheller
• Subject Area: Cell Biology ; Biochemistry
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 438049395

• Final Report Year: 2024

No abstract available

Publications

• A variant in IL6ST with a selective IL-11 signaling defect in human and mouse. Bone Research, 8(1).
  Schwerd, Tobias; Krause, Freia; Twigg, Stephen R. F.; Aschenbrenner, Dominik; Chen, Yin-Huai; Borgmeyer, Uwe; Müller, Miryam; Manrique, Santiago; Schumacher, Neele; Wall, Steven A.; Jung, Jonathan; Damm, Timo; Glüer, Claus-Christian; Scheller, Jürgen; Rose-John, Stefan; Jones, E. Yvonne; Laurence, Arian; Wilkie, Andrew O. M.; Schmidt-Arras, Dirk & Uhlig, Holm H.
  
• Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc. Cytokine: X, 3(4), 100058.
  Berg, Anna F.; Ettich, Julia; Weitz, Hendrik T.; Krusche, Matthias; Floss, Doreen M.; Scheller, Jürgen & Moll, Jens M.
  
• Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion. Science Signaling, 14(696).
  Heise, Denise; Derrac, Soria Alicia; Hansen, Selina; Dambietz, Christine; Akbarzadeh, Mohammad; Berg, Anna F.; Waetzig, Georg H.; Jones, Simon A.; Dvorsky, Radovan; Ahmadian, Mohammad R.; Scheller, Jürgen & Moll, Jens M.
  
• A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans -Signaling and Cellular Infection with SARS-CoV-2. Journal of Virology, 96(4).
  Ettich, Julia; Werner, Julia; Weitz, Hendrik T.; Mueller, Eva; Schwarzer, Roland; Lang, Philipp A.; Scheller, Jürgen & Moll, Jens M.
  
• Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling. Journal of Biological Chemistry, 299(11), 105343.
  Gesiorowski, Annika; Ettich, Julia; Werner, Julia; Wittich, Christoph; Pieper, Stephan; Padrini, Giacomo; Behnke, Kristina; Floss, Doreen M.; Lang, Philipp A.; Moll, Jens M. & Scheller, Jürgen
  
• Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes. Communications Biology, 6(1).
  Rafii, Puyan; Seibel, Christiane; Weitz, Hendrik T.; Ettich, Julia; Minafra, Anna Rita; Petzsch, Patrick; Lang, Alexander; Floss, Doreen M.; Behnke, Kristina; Köhrer, Karl; Moll, Jens M. & Scheller, Jürgen
  
• Targeting IL-6 trans-signalling: past, present and future prospects. Nature Reviews Immunology, 23(10), 666-681.
  Rose-John, Stefan; Jenkins, Brendan J.; Garbers, Christoph; Moll, Jens M. & Scheller, Jürgen
  
• Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR. Journal of Biological Chemistry, 300(5), 107251.
  Rafii, Puyan; Cruz, Patricia Rodrigues; Ettich, Julia; Seibel, Christiane; Padrini, Giacomo; Wittich, Christoph; Lang, Alexander; Petzsch, Patrick; Köhrer, Karl; Moll, Jens M.; Floss, Doreen M. & Scheller, Jürgen