The role of mitochondria for cellular protection against ferroptosis (A06)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

Mitochondria play an active role in cell death control and are emerging as central regulators of innate immunity. In addition to their well-described role in apoptosis, mitochondria have also been linked to other modes of regulated cell death, such as necroptosis, ferroptosis and pyroptosis. This project will examine how the mitochondrial i-AAA protease YME1L regulates cell survival, and inflammatory responses on a molecular level and how this relates to neurodegeneration and tissue-specific cell death in vivo. These studies will help define the role of mitochondria at the interface between cell death and inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Thomas Langer