Untersuchung der molekularen Mechanismen der beiden Syndrome Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) and Ectrodactyly-ectodermal dysplasia-clefting (EEC)

Antragsteller Professor Dr. Volker Dötsch; Professor Dr. Christian Münch

Fachliche Zuordnung Biochemie
Strukturbiologie

Förderung Förderung von 2020 bis 2023

Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 439918811

Erstellungsjahr 2024

Keine Zusammenfassung vorhanden

Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis. Cell Reports, 41(3), 111503.
Al Moussawi, Khatoun; Chung, Kathryn; Carroll, Thomas M.; Osterburg, Christian; Smirnov, Artem; Lotz, Rebecca; Miller, Paul; Dedeić, Zinaida; Zhong, Shan; Oti, Martin; Kouwenhoven, Evelyn N.; Asher, Ruth; Goldin, Robert; Tellier, Michael; Murphy, Shona; Zhou, Huiqing; Dötsch, Volker & Lu, Xin
ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection. Journal of General Virology, 104(9).
Smirnov, Artem; Magri, Andrea; Lotz, Rebecca; Han, Xiaoyue; Yin, Chunhong; Harris, Mark; Osterburg, Christian; Dötsch, Volker; McKeating, Jane A. & Lu, Xin
Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree. Cell Death & Disease, 14(4).
Osterburg, Christian; Ferniani, Marco; Antonini, Dario; Frombach, Ann-Sophie; D.’Auria, Ludovica; Osterburg, Susanne; Lotz, Rebecca; Löhr, Frank; Kehrloesser, Sebastian; Zhou, Huiqing; Missero, Caterina & Dötsch, Volker
Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α. Scientific Reports, 13(1).
Lambert, Mahil; Gebel, Jakob; Trejtnar, Charlotte; Wesch, Nicole; Bozkurt, Süleyman; Adrian-Allgood, Martin; Löhr, Frank; Münch, Christian & Dötsch, Volker

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