Investigation of the disease mechanism causing Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome and Ectrodactyly-ectodermal dysplasia-clefting syndrome

• Applicants: Professor Dr. Volker Dötsch; Professor Dr. Christian Münch
• Subject Area: Biochemistry ; Structural Biology
• Term: from 2020 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439918811

• Final Report Year: 2024

No abstract available

Publications

• Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis. Cell Reports, 41(3), 111503.
  Al Moussawi, Khatoun; Chung, Kathryn; Carroll, Thomas M.; Osterburg, Christian; Smirnov, Artem; Lotz, Rebecca; Miller, Paul; Dedeić, Zinaida; Zhong, Shan; Oti, Martin; Kouwenhoven, Evelyn N.; Asher, Ruth; Goldin, Robert; Tellier, Michael; Murphy, Shona; Zhou, Huiqing; Dötsch, Volker & Lu, Xin
  
• ASPP2 binds to hepatitis C virus NS5A protein via an SH3 domain/PxxP motif-mediated interaction and potentiates infection. Journal of General Virology, 104(9).
  Smirnov, Artem; Magri, Andrea; Lotz, Rebecca; Han, Xiaoyue; Yin, Chunhong; Harris, Mark; Osterburg, Christian; Dötsch, Volker; McKeating, Jane A. & Lu, Xin
  
• Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree. Cell Death & Disease, 14(4).
  Osterburg, Christian; Ferniani, Marco; Antonini, Dario; Frombach, Ann-Sophie; D.’Auria, Ludovica; Osterburg, Susanne; Lotz, Rebecca; Löhr, Frank; Kehrloesser, Sebastian; Zhou, Huiqing; Missero, Caterina & Dötsch, Volker
  
• Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α. Scientific Reports, 13(1).
  Lambert, Mahil; Gebel, Jakob; Trejtnar, Charlotte; Wesch, Nicole; Bozkurt, Süleyman; Adrian-Allgood, Martin; Löhr, Frank; Münch, Christian & Dötsch, Volker