Influence of environmental factors on the interplay of transcriptome and proteome in newly diagnosed Multiple Sclerosis patients

• Applicants: Professor Nicholas Schwab, Ph.D.; Professor Dr. Heinz Wiendl
• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology ; Molecular and Cellular Neurology and Neuropathology
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 445569437

• Final Report Year: 2024

Final Report Abstract

Multiple Sclerosis is a neuroinflammatory disorder, where the incidence and -severity is influenced by environmental factors like smoking, weight, diet and sun exposure. This project aims to identify how these factors alter the transcriptome and proteome of newly diagnosed MS patients and analyze if there are common nodes or checkpoints that mediate environmental stimuli.

Publications

• Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis. Journal of Experimental Medicine, 219(11).
  Schneider-Hohendorf, Tilman; Gerdes, Lisa Ann; Pignolet, Béatrice; Gittelman, Rachel; Ostkamp, Patrick; Rubelt, Florian; Raposo, Catarina; Tackenberg, Björn; Riepenhausen, Marianne; Janoschka, Claudia; Wünsch, Christian; Bucciarelli, Florence; Flierl-Hecht, Andrea; Beltrán, Eduardo; Kümpfel, Tania; Anslinger, Katja; Gross, Catharina C.; Chapman, Heidi; Kaplan, Ian ... & Schwab, Nicholas
  
• Analysis of the Adaptive Immune Receptor Repertoire Alongside Treatment with Ocrelizumab Suggests Clinical Relevance of B-cell Repopulation Versus Reconstruction”. MSMilan2023 – LB Paper Posters – Session 2. Multiple Sclerosis Journal. 2023;29(3_suppl):1082-1108
  Schneider-Hohendorf, Tilman
  
• Chemokine-triggered migration into the CNS during MS and its modulation by treatment with natalizumab or during PML. MSMilan2023 – Paper Poster - Session 1. Multiple Sclerosis Journal. 2023;29(3_suppl):137-393
  Deffner, Marie
  
• Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation. Brain, 148(3), 933-940.
  Schneider-Hohendorf, Tilman; Wünsch, Christian; Falk, Simon; Raposo, Catarina; Rubelt, Florian; Mirebrahim, Hamid; Asgharian, Hosseinali; Schlecht, Ulrich; Mattox, Daniel; Zhou, Wenyu; Dawin, Eva; Pawlitzki, Marc; Lauks, Sarah; Jarius, Sven; Wildemann, Brigitte; Havla, Joachim; Kümpfel, Tania; Schrot, Miriam-Carolina; Ringelstein, Marius ... & Schwab, Nicholas
  
• Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation. ECTRIMS 2024 – Late Breaking Oral Presentations. Multiple Sclerosis Journal. 2024;30(3_suppl):1138-1147
  Schneider-Hohendorf, Tilman
  
• Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy. Cell Reports Medicine, 5(7), 101622.
  Deffner, Marie; Schneider-Hohendorf, Tilman; Schulte-Mecklenbeck, Andreas; Falk, Simon; Lu, I.-Na; Ostkamp, Patrick; Müller-Miny, Louisa; Schumann, Eva Maria; Goelz, Susan; Cahir-McFarland, Ellen; Thakur, Kiran T.; De Jager, Philip L.; Klotz, Luisa; Meyer, zu Hörste, Gerd; Gross, Catharina C.; Wiendl, Heinz; Grauer, Oliver M. & Schwab, Nicholas
  
• Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA. Brain, 147(2), 333-334.
  Schwab, Nicholas