Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake (P02)

• Subject Area: Pharmacology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

Tanycytes are important gatekeepers to transport TH into the CNS. Tanycytes themselves react to TH, which could modulate essential functions of tanycytes, such as their morphology or the transport of hormones. This project will focus on the role of TH in tanycytic functions and will clarify their effects on tanycytic morphology and hormonal transport into the cerebrospinal fluid. Additionally, this project will clarify the importance of local tanycytic distribution of TH into the VMH, which has an influence on liver metabolism.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Dr. Helge Müller-Fielitz