Transporter expression and TH action in the brain (P03)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

MCT8 is a specific TH transporter in the brain. In this project, spatiotemporal expression of MCT8 from early weeks of gestation to adult healthy and diseased human brains will be examined. In a complementary approach, we will develop MCT8 reporter stem cell models to monitor MCT8 expression during cerebral organoid differentiation and development and to enable enrichment of MCT8-expressing neuronal cell types for transcriptome analyses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Ingo Bechmann; Professorin Dr. Heike Biebermann