A brain imaging approach to TH function in consequence to mutations in TH receptors and transporter proteins (P07)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

TH action is critical for the human brain. TH action is mediated by a number of molecules, e.g. TH transporters and receptors (THT, TR). We aim to demonstrate that genetic variations in THTs and TRs contribute to the neuropsychological phenotype and, by using multimodal brain imaging and electrophysiology, will identify the underlying systems-level neural mechanisms.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Privatdozentin Dr. Anna Cirkel; Professor Dr. Thomas F. Münte