Strategies to increase local T3 availability in liver (P16)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

T3 is a key regulator of hepatic lipid metabolism. Hypothyroidism has been linked to non-alcoholic (obesity-/ diabetes-associated) hepatosteatosis and its sequelae. We aim to elevate local T3 concentrations by steering activities of T3-degrading deiodinase isozymes in hepatocytes by using selective deiodinase (DIO) isozyme inhibitors. Local T3 effects will be monitored by T3-sensitive reporter constructs expressed in THAI mouse-derived primary hepatocyte cultures and hiPSC-derived hepatocyte cell lines.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Josef Köhrle; Dr. Eva K. Wirth