| Retuning pathway-specific neuronal population dynamics for movement initiation (A04)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases ; Experimental and Theoretical Network Neuroscience
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Our goal is to understand and modulate movement-related neural dynamics at the neuronal level. Using state-of-the-art Neuropixels probes, we will simultaneously record hundreds of neurons in the cortex and basal ganglia of awake behaving mice. Combining these large-scale recordings with pathway-specific optogenetics and electrical stimulation in PD mouse models, we will elucidate how Parkinson’s disease affects distributed neural dynamics and identify mechanisms of deep brain stimulation. Cross-species analysis of oscillatory dynamics will facilitate the translation of our findings to humans. By identifying the therapeutically relevant neural dynamics for improving motor deficits, this project will pave the way towards more sophisticated neuromodulation therapies of PD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Wolf-Julian Neumann; Dr. Yangfan Peng; Professor Dr. Philip Tovote