Closed-loop neurostimulation in MPTP monkeys (C03)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

In this project, we will assemble a comprehensive database of the functional connectivity within and between nuclei of the basal ganglia of non-human primates throughout the sleep-wake cycle, before and following MPTP intoxication and development of Parkinson’s disease. This information will enable us to design frequency- and phase-specific closed-loop deep brain stimulation therapy that adapts to the circadian rhythm and thereby improves the quality of life of upcoming generations of Parkinson’s disease patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• International Connection: Israel
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professor Dr. Hagai Bergman