Exploring the capacity of cutting-edge adaptive DBS techniques to modulate disease progression in the chronic low-dose MPTP non-human primate model of Parkinson's disease (C03)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Sleep is essential for life and good health. Patients with REM sleep behavior disorder (RBD) will often develop Parkinson’s disease (PD) within few years. Our previous studies (conducted in the first ReTune funding period) revealed that the basal ganglia have a critical role in developing PD sleep disorders. In the second funding period we aim at the restoration of normal sleep architecture of non-human primates with RBD by circadian, frequency, and phase-specific closed-loop Deep Brain stimulation (clDBS). We hope to show that clDBS would slow (stop) the progression of sleep disorders and Parkinson’s disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• International Connection: Israel
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professor Dr. Hagai Bergman