NMDA receptor-dependent prefrontal circuits critical for cognitive flexibility (A01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

The NMDA receptor complex is crucial for cognitive flexibility, but its clinically useful properties and potential are still largely unclear. We will, therefore, investigate the molecular and cellular properties of the NMDA receptor complex using a complementary molecular biochemical and behavioral pharmacological approach, focusing on the prefrontal cortex and associated circuits. Our aim is to find new drug targets for therapeutic intervention strategies for deficits in cognitive flexibility in aging and neurodegenerative diseases and to explore the potential of NMDA receptor-dependent circuits in a more general manner.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professorin Dr. Daniela C. Dieterich; Professor Dr. Markus Fendt; Professor Dr. Thomas Nickl-Jockschat