The NMDA receptor complex - a signalling hub at the origin of cognitive flexibility? (A01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

The aim of our project is to unravel the contribution of the NMDAR signalling hub to cognitive flexibility. We will focus our analysis on subregions of the frontal cortex involved in cognitive flexibility. We will combine a sophisticated behavioural paradigm in mice (attentional set shifting) with state-of-the-art, highly sensitive proteome analyses deciphering molecular, cellular and network properties of cognitive flexibility. In particular, the effect of age, environmental and cognitive enrichment, and circadian strain on the NMDAR signalling hub will be assessed with the aim to identify key players in the different subregions of the frontal cortex.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professorin Dr. Daniela C. Dieterich; Professor Dr. Markus Fendt