Neural resource allocation by spatial memory circuits facing progressive pathological challenges (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this project we will assess the neural resource allocation within the hippocampal circuitry during spatial learning and test interventional strategies based on ameliorating inhibitory circuit function as the circuitry is gradually challenged by unifactorial (beta-amyloid deposition) and multifactorial pathology (additional metabolic-vascular comorbidities) associated with a high-fat/high-glucose diet. We will investigate using in-depth analyses of hippocampal oscillatory cross-frequency coupling, multiphoton Ca2+ imaging and deep-learning-based behavioural quantification in mice how performance prediction within the neural feature space correlates with behavioural performance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Privatdozent Dr. Stefan Dürschmid; Professor Dr. Stefan Remy