Grid cell integrity as a neural resource for navigation and episodic memory? (B03)

• Subject Area: Human Cognitive and Systems Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

Grid cells (GC) in the entorhinal cortex represent a fundamental neural resource for organising, navigating and updating mnemonic spaces. As such, they provide a unique window into the mechanisms underlying the variability of navigational functioning across individuals and a novel avenue for improving navigational abilities and episodic memory. With its meso-scale level of analysis, this project will investigate (i) the functional and physiological mechanisms that support GC integrity, (ii) how GC computations can be modulated with interventions targeting sleep and neuronal replay, and (iii) whether GC stability contributes to SuperAgeing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Kevin Allen, until 4/2024; Professorin Dr. Hannah Monyer, since 5/2024; Dr. Vladislava Segen, since 9/2022; Jonathan Shine, Ph.D., until 10/2021; Professor Dr. Thomas Wolbers