From Alzheimer’s Disease to SuperAgeing: A Cross-Species Study on Grid Cells as a central resource for Memory and Navigation (B03)

• Subject Area: Human Cognitive and Systems Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

The grid cell system in the entorhinal cortex serves as a fundamental architecture for organizing and navigating mnemonic space. Our goal is to probe this system functionally and behaviourally in rodents and humans, and test the hypothesis that differential vulnerability of this system accounts in large parts for the decline and preservation, respectively, in cognitive abilities in subjects with neurodegenerative pathologies versus normally-aged subjects or SuperAgers.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Kevin Allen, until 4/2024; Professorin Dr. Hannah Monyer, since 5/2024; Dr. Vladislava Segen, from 9/2022 until 12/2024; Jonathan Shine, Ph.D., until 10/2021; Professor Dr. Thomas Wolbers