Visceral and subcutaneous dendritic cell subset-specific transcriptional and functional specializations during metaflammation (P05)

• Subject Area: Immunology ; Nutritional Sciences
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

We have shown that cDC1 and cDC2 dendric cells are rapidly lost upon induction of metaflammation in the bone marrow and subcutaneous white adipose tissue (scWAT), but not visceral WAT (vWAT). To investigate the underlying mechanisms, we will analyze the role of prostaglandin E2 (PGE2) signalling, which is key in regulating inflammatory amplitude in the adipose tissue, for DC subset survival, proliferation, and function within their respective cellular neighbourhoods during homeostasis and diet-induced metaflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Andreas Schlitzer