Metaflammation induced alterations in eosinophil-Treg cell crosstalk in the gonadal white adipose tissue (P16)

• Subject Area: Immunology ; General Genetics and Functional Genome Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

We found that high-fat diet (HFD) decreased the numbers of Treg cells and eosinophils in the adipose tissue, independent of HIF1α in tissue macrophages. We now aim to study whether eosinophils and their crosstalk with Treg cells are a major determinant of the local and systemic inflammatory response driving metaflammation, focusing on the effect of dietary modulation exerted by AHR ligands on adipose eosinophil programming and their interplay with Treg cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Privatdozent Dr. Marc Beyer; Nicola Laura Diny, Ph.D., since 1/2025