The role of primary cilia in controlling metaflammation (P18)

• Subject Area: Immunology ; Endocrinology, Diabetology, Metabolism ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Adipocyte dysfunction in response to excess food intake contributes to a low-grade inflammation, called metaflammation. We hypothesize that primary cilia on pre-adipocytes can sense the metabolic state and control adipocyte function and, thereby, regulate the inflammatory response in the adipose tissue. This project we will provide a comprehensive analysis of how primary cilia regulate metaflammation and combine the knowledge gained from mouse models and human patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professorin Dr. Dagmar Wachten