TRR 333:  Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)

• Subject Area: Medicine ; Biology
• Term: since 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• MGK - Module Integrated Research Training Group (iRTG) (Project Heads Fenske, Wiebke Kristin ;  Klingenspor, Martin ;  Worthmann, Anna )
• P01 - Bariatric surgery as a key model to unravel microbiome-based treatment targets modulating adipose tissue thermogenesis (Project Head Fenske, Wiebke Kristin )
• P02 - Intestinal metabolites and their impact on thermogenic responses by brown and white adipose tissues (Project Heads Heeren, Jörg ;  Schwinge, Dorothee )
• P03 - Investigating novel endocrine signals of liver – white and brown adipose tissue cross talk in response to cold exposure and feeding cues (Project Heads Georgiadi, Ph.D., Anastasia ;  Herzig, Stephan )
• P04 - ExBat: Effect of acute and chronic exercise on human thermogenic adipose tissue & elucidation of mechanisms (Project Heads Soriano-Arroquia, Ph.D., Ana ;  Wackerhage, Henning )
• P05 - Relevance of endothelial lipoprotein processing for thermogenic adipose tissue plasticity and function (Project Head Heeren, Jörg )
• P06 - Interactions of endothelium and adipocytes during thermogenic adaptation (Project Heads Pfeifer, Alexander ;  Wilhelm-Jüngling, Kerstin )
• P07 - Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages (Project Heads Bosurgi, Ph.D., Lidia ;  Worthmann, Anna )
• P08 - Metabolic regulation through the aryl hydrocarbon receptor repressor (AhRR) via immune cell/adipocyte interactions (Project Head Förster, Irmgard )
• P09 - Paracrine fibroblast growth factors as metabolic messengers between adipose tissue cells (Project Head Fromme, Tobias )
• P10 - Regulation and adaptation of G-protein coupled receptors/adenylyl cyclase/cAMP signaling networks in brown/beige AT (Project Heads Pfeifer, Alexander ;  Wachten, Dagmar )
• P11 - Purinergic crosstalk in thermogenic fat – Regulation of adenosine release by ENT1 (Project Heads Gnad, Thorsten ;  Pfeifer, Alexander )
• P12 - The role of ACTH and glucocorticoid signaling in brown fat metabolism (Project Heads Li, Yongguo ;  Uhlenhaut, Nina Henriette )
• P13 - The role of ChREBP-dependent de novo lipogenesis in metabolic and thermogenic activities of brown and white adipose tissue (Project Head Scheja, Ludger )
• P14 - Molecular role of the mitochondrial unfolded protein response in white and brown adipose tissue for whole body glucose homeostasis (Project Heads Klingenspor, Martin ;  Rath, Eva )
• P15 - Impact of mitochondrial lipogenesis on thermogenic function and interorganelle crosstalk of brown adipocytes (Project Head Schlein, Christian )
• P16 - Proteomic analysis of brown adipocyte organelle dynamics and contact site formation (Project Head Krahmer, Natalie )
• P17 - The role of fatty acid/triglyceride cycling in maintenance of mitochondrial integrity and cellular health, and its contribution to thermogenesis in adipose tissues (Project Head Klingenspor, Martin )
• S01 - Computational Biology Unit (Project Head Hasenauer, Jan )
• S02 - Functional Proteomics/Metabolomics/Lipidomics and Human Adipocyte Unit (Project Heads Dyar, Ph.D., Kenneth A. ;  Meissner, Felix ;  Pfeifer, Alexander )
• Z01 - Central Tasks (Project Head Pfeifer, Alexander )

• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Co-Applicant Institution: Technische Universität München (TUM); Universität Hamburg
• Spokesperson: Professor Dr. Alexander Pfeifer