Untersuchung komplexer Ausgangssignale vom Subikulum in kortikalen und subkortikalen Strukturen
Experimentelle und theoretische Netzwerk-Neurowissenschaften
Zusammenfassung der Projektergebnisse
The mammillary bodies (MBO), a group of hypothalamic nuclei, play a pivotal role in memory formation and spatial navigation. They receive extensive inputs from the hippocampus through the fornix, but the precise nature and physiological significance of these connections remain poorly understood. Damage to the MBO is frequently associated with various forms of anterograde amnesia, a condition characterized by an inability to form new memories. However, the specific computations performed by the MBO are still largely unknown, primarily due to the limited number of studies that have directly monitored MBO activity during natural behavior. Employing large-coverage high-density silicon probe recording in mice, I characterized MBO activity and its interaction with the hippocampus across various brain states. I found that the physiological subdivisions of spiking activity in the mammillary body correspond to three parallel streams of anatomical organization yet with distinct behavioral functions. These distinctions are based on upstream influences from hippocampal regions, such as theta oscillations and SPW-Rs, monosynaptic connections and behavioral correlates.
Projektbezogene Publikationen (Auswahl)
-
Brain-wide interactions during hippocampal sharp wave ripples. Proceedings of the National Academy of Sciences, 119(20).
Nitzan, Noam; Swanson, Rachel; Schmitz, Dietmar & Buzsáki, György
-
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice. Nature Neuroscience, 26(4), 570-578.
Soula, Marisol; Martín-Ávila, Alejandro; Zhang, Yiyao; Dhingra, Annika; Nitzan, Noam; Sadowski, Martin J.; Gan, Wen-Biao & Buzsáki, György
