Peritoneal immune states link gut and liver pathology in cirrhosis (B07)

• Subject Area: Gastroenterology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Failure of intestinal barriers and immune dysfunction both contribute to the translocation of microbial products in patients with cirrhosis, which perpetuates inflammation, promotes infection, and accelerates organ failure. Resident peritoneal immune cells are repeatedly exposed to bacterial products, and their activation status is linked to complications. Project B07 will decipher aspects of human peritoneal immune dysfunction in the context of bacterial translocation and explore the consequences of therapeutic encapsulated fecal microbiota transplantation (eFMT) on gut microbiota composition, intestinal barrier function, and peritoneal immune activation in patients with cirrhosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Tony Bruns; Professorin Dr. Maria J G T Vehreschild, since 7/2023