Regulation of vascular permeability and leukocyte extravasation in inflammation: mechanisms and heterogeneity in different organs (B03+)

• Subject Area: Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

It has recently emerged that the molecular mechanisms and requirements which control the integrity of the endothelial barrier vary significantly between different organs. This project will analyse how VE-cadherin regulates vascular permeability of the endothelium in different tissues. In a second part, it will be investigated whether the preferential use of the leukocyte diapedesis route through endothelium (trans-junctional versus transcellular) varies in different organs and which molecular mechanisms influence this choice.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Dietmar Vestweber