Metabolic priming of monocytes during inflammation in vivo (C01)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology ; Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

During systemic inflammation, shifts in metabolism lead to a secondary immune tolerance with a life-threatening defective antimicrobial defence. We demonstrated significant metabolic alterations during tolerance in monocytes. We will now target specific metabolic pathways in monocytes to analyse functional consequences. We will use metabolic radiotracers and innovative tracking strategies to confirm their relevance in infections and sterile inflammation. Our final goal is the identification of metabolites which could be used as innovative tracers for imaging specific disease stages or therapeutic targets for inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Johannes Roth; Professor Dr. Michael Schäfers