Importance of microglial tissue surveillance for neural development and function (A10*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Microglia are highly dynamic cells that continuously survey the brain. This enables them tophysiologically interact with neurons, which is critical for neural development and function. We recentlydiscovered that THIK-1 potassium channels regulate microglial ramification, surveillance and cytokinerelease. Since these parameters may be crucial to shape inter-actions with neurons, we will explorethe role of microglial surveillance in neural function by electrophysiological analyses using THIK-1 KOmouse models. This will be done in the developing and adult brain, as well as under physiological andpathological conditions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Christian Madry