Innate immune circuits for bone maintenance and regeneration (P11)

• Subject Area: Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188

Triantafyllopoulou and Diefenbach will analyse innate immune circuits for bone maintenance and regeneration. There is ample evidence that in tissues other than bone, innate lymphoid cells (ILC) and myeloid cell crosstalk plays a major role in tissue regeneration. Triantafyllopoulou and Diefenbach will investigate the role of the microbiota and type I interferons in regulating osteoclast development and maintenance. They hypothesise that the balance of bone marrow resident ILC1, secreting TNF and IFNγ and ILC2, secreting type 2 cytokines, crucially regulate macrophage precursor cell fate decisions in the bone marrow and thus osteoclastogenesis. Their goal is to determine the role of the microbiota-ILC-osteoclast progenitor axis in bone regeneration under physiological conditions and in the context of compromised healing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1444: Directed Cellular Self-Organisation for Advancing Bone Regeneration
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Andreas Diefenbach; Professorin Dr. Antigoni Triantafyllopoulou