Impact of the central nervous system on metabolic and immunological responses, particularly focusing on adrenergic signaling and circadian rhythm in bone and fracture following trauma (P15)

• Subject Area: Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188

This project hypothesizes that the beta-adrenergic signalling plays a key role in immunological and metabolic processes in bone and fracture following central nervous system trauma (brain and spinal cord). Furthermore, it focuses on the cellular circadian clock, as a major downstream target of ADRB2 in bone cells and analyses the effect of trauma-related ADRB2 stimulation on the rhythmic gene expression in intact and fractured bones and their associated functional changes. This knowledge contributes to personalized therapeutic strategies for patients suffering from impaired fracture healing and complex trauma settings.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1444: Directed Cellular Self-Organization to Advance Bone Regeneration
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Denise Jahn, since 1/2025; Privatdozent Dr. Matthias Pumberger; Privatdozent Serafeim Tsitsilonis, Ph.D., until 12/2024