Migration, Differenzierung und funktionelle Rolle von Monozyten-Subpopulationen in vivo

• Antragsteller: Professor Frank Tacke, Ph.D.
• Fachliche Zuordnung: Gastroenterologie
• Förderung: Förderung von 2007 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 45277512

• Erstellungsjahr: 2015

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• High C5a levels are associated with increased mortality in sepsis patients - no enhancing effect by actin-free Gc-globulin. Clinical Biochemistry, Vol. 41. 2008, Issue 12, pp. 974-980.
  Gressner, Olav A.; Koch, Alexander; Sanson, Edouard; Trautwein, Christian & Tacke, Frank
  
• The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biological Chemistry, Bd. 390. 2009, Heft 10, S. 1039–1045.
  Berres, Marie-Luise; Trautwein, Christian; Zaldivar, Mirko Moreno; Schmitz, Petra; Pauels, Katrin; Lira, Sergio A.; Tacke, Frank & Wasmuth, Hermann E.
  
• Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunology, Vol. 11. 2010, Issue 1: 30.
  Seidler, Sebastian; Zimmermann, Henning W; Bartneck, Matthias; Trautwein, Christian & Tacke, Frank
  
• Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis. PLoS ONE, Vol. 6. 2011, Issue 6: e21381.
  Zimmermann, Henning W.; Seidler, Sebastian; Gassler, Nikolaus; Nattermann, Jacob; Luedde, Tom; Trautwein, Christian & Tacke, Frank
  
• Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflammation & Allergy-Drug Targets, Vol. 10. 2011, Number 6, pp. 509-536.
  W. Zimmermann, Henning & Tacke, Frank
  
• Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis. Clinical Biochemistry, Vol. 45. 2012, Issue 6, pp. 429-435.
  Koch, Alexander; Zimmermann, Henning W.; Baeck, Christer; Schneider, Carlo; Yagmur, Eray; Trautwein, Christian & Tacke, Frank
  
• Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation. Immunity, Vol. 37. 2012, Issue 5, pp. 905-916.
  Seré, Kristin; Baek, Jea-Hyun; Ober-Blöbaum, Julia; Müller-Newen, Gerhard; Tacke, Frank; Yokota, Yoshifumi; Zenke, Martin & Hieronymus, Thomas
  
• Frequency and Phenotype of Human Circulating and Intrahepatic Natural Killer Cell Subsets Is Differentially Regulated according to Stage of Chronic Liver Disease. Digestion, Vol.88. 2013, No. 1, pp. 1-16.
  Zimmermann, Henning Wolfgang; Mueller, Jan Robert; Seidler, Sebastian; Luedde, Tom; Trautwein, Christian & Tacke, Frank
  
• TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6C(hi) Monocytes during Entamoeba histolytica Infection. PLOS Pathogens, Vol. 9. 2013, Issue 1: e1003096.
  Helk, Elena; Bernin, Hannah; Ernst, Thomas; Ittrich, Harald; Jacobs, Thomas; Heeren, Joerg; Tacke, Frank; Tannich, Egbert & Lotter, Hannelore
  
• Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 10. 2014, Issue 6, pp. 1209-1220.
  Bartneck, Matthias; Peters, Franziska Marie; Warzecha, Klaudia Theresa; Bienert, Michaela; van Bloois, Louis; Trautwein, Christian; Lammers, Twan & Tacke, Frank
  
• Macrophage heterogeneity in liver injury and fibrosis. Journal of Hepatology, Vol. 60. 2014, Issue 5, pp. 1090-1096.
  Tacke, Frank & Zimmermann, Henning W.
  
• Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. Biomaterials, Vol. 37. 2015, pp. 367-382.
  Bartneck, Matthias; Scheyda, Katharina M.; Warzecha, Klaudia T.; Rizzo, Larissa Y.; Hittatiya, Kanishka; Luedde, Tom; Storm, Gert; Trautwein, Christian; Lammers, Twan & Tacke, Frank
  
• Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology, Vol. 62. 2015, Issue 1, pp. 279-291.
  Heymann, Felix; Peusquens, Julia; Ludwig‐Portugall, Isis; Kohlhepp, Marlene; Ergen, Can; Niemietz, Patricia; Martin, Christian; van Rooijen, Nico; Ochando, Jordi C.; Randolph, Gwendalyn J.; Luedde, Tom; Ginhoux, Florent; Kurts, Christian; Trautwein, Christian & Tacke, Frank