Migration, Differenzierung und funktionelle Rolle von Monozyten-Subpopulationen in vivo

• Antragsteller: Professor Dr. Frank Tacke, Ph.D.
• Fachliche Zuordnung: Gastroenterologie
• Förderung: Förderung von 2007 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 45277512

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• High C5a levels are associated with increased mortality in sepsis patients - no enhancing effect by actin-free Gc-globulin. Clinical Biochemistry, Vol. 41. 2008, Issue 12, pp. 974-980.
  Gressner O.A., Koch A., Sanson E., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1016/j.clinbiochem.2008.05.005)
• The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biological Chemistry, Bd. 390. 2009, Heft 10, S. 1039–1045.
  Berres M.L., Trautwein C., Zaldivar M.M., Schmitz P., Pauels K., Lira S.A., Tacke F., Wasmuth H.E.
  (Siehe online unter https://doi.org/10.1515/BC.2009.119)
• Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunology, Vol. 11. 2010, Issue 1: 30.
  Seidler S., Zimmermann H.W., Bartneck M., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1186/1471-2172-11-30)
• Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis. PLoS ONE, Vol. 6. 2011, Issue 6: e21381.
  Zimmermann H.W., Seidler S., Gassler N., Nattermann J., Luedde T., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1371/journal.pone.0021381)
• Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflammation & Allergy-Drug Targets, Vol. 10. 2011, Number 6, pp. 509-536.
  Zimmermann H.W., Tacke F.
  (Siehe online unter https://doi.org/10.2174/187152811798104890)
• Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis. Clinical Biochemistry, Vol. 45. 2012, Issue 6, pp. 429-435.
  Koch A., Zimmermann H.W., Baeck C., Schneider C., Yagmur E., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1016/j.clinbiochem.2012.01.009)
• Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation. Immunity, Vol. 37. 2012, Issue 5, pp. 905-916.
  Seré K., Baek J.H., Ober-Blöbaum J., Müller-Newen G., Tacke F., Yokota Y., Zenke M., Hieronymus T.
  (Siehe online unter https://doi.org/10.1016/j.immuni.2012.07.019)
• Frequency and Phenotype of Human Circulating and Intrahepatic Natural Killer Cell Subsets Is Differentially Regulated according to Stage of Chronic Liver Disease. Digestion, Vol.88. 2013, No. 1, pp. 1-16.
  Zimmermann H.W., Mueller J.R., Seidler S., Luedde T., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1159/000350821)
• TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6C(hi) Monocytes during Entamoeba histolytica Infection. PLOS Pathogens, Vol. 9. 2013, Issue 1: e1003096.
  Helk E., Bernin H., Ernst T., Ittrich H., Jacobs T., Heeren J., Tacke F., Tannich E., Lotter H.
  (Siehe online unter https://doi.org/10.1371/journal.ppat.1003096)
• Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 10. 2014, Issue 6, pp. 1209-1220.
  Bartneck M., Peters F.M., Warzecha K.T., Bienert M., van Bloois L., Trautwein C., Lammers T., Tacke F.
  (Siehe online unter https://doi.org/10.1016/j.nano.2014.02.011)
• Macrophage heterogeneity in liver injury and fibrosis. Journal of Hepatology, Vol. 60. 2014, Issue 5, pp. 1090-1096.
  Tacke F., Zimmermann H.W.
  (Siehe online unter https://doi.org/10.1016/j.jhep.2013.12.025)
• Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. Biomaterials, Vol. 37. 2015, pp. 367-382.
  Bartneck M., Scheyda K.M., Warzecha K.T., Rizzo L.Y., Hittatiya K., Luedde T., Storm G., Trautwein C., Lammers T., Tacke F.
  (Siehe online unter https://doi.org/10.1016/j.biomaterials.2014.10.030)
• Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology, Vol. 62. 2015, Issue 1, pp. 279-291.
  Heymann F., Peusquens J., Ludwig-Portugall I., Kohlhepp M., Ergen C., Niemietz P., Martin C., van Rooijen N., Ochando J.C., Randolph G.J., Luedde T., Ginhoux F., Kurts C., Trautwein C., Tacke F.
  (Siehe online unter https://doi.org/10.1002/hep.27793)