Migration, Differenzierung und funktionelle Rolle von Monozyten-Subpopulationen in vivo

• Applicant: Professor Dr. Frank Tacke, Ph.D.
• Subject Area: Gastroenterology
• Term: from 2007 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 45277512

• Final Report Year: 2015

Final Report Abstract

No abstract available

Publications

• High C5a levels are associated with increased mortality in sepsis patients - no enhancing effect by actin-free Gc-globulin. Clinical Biochemistry, Vol. 41. 2008, Issue 12, pp. 974-980.
  Gressner O.A., Koch A., Sanson E., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1016/j.clinbiochem.2008.05.005)
• The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biological Chemistry, Bd. 390. 2009, Heft 10, S. 1039–1045.
  Berres M.L., Trautwein C., Zaldivar M.M., Schmitz P., Pauels K., Lira S.A., Tacke F., Wasmuth H.E.
  (See online at https://doi.org/10.1515/BC.2009.119)
• Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunology, Vol. 11. 2010, Issue 1: 30.
  Seidler S., Zimmermann H.W., Bartneck M., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1186/1471-2172-11-30)
• Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis. PLoS ONE, Vol. 6. 2011, Issue 6: e21381.
  Zimmermann H.W., Seidler S., Gassler N., Nattermann J., Luedde T., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1371/journal.pone.0021381)
• Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflammation & Allergy-Drug Targets, Vol. 10. 2011, Number 6, pp. 509-536.
  Zimmermann H.W., Tacke F.
  (See online at https://doi.org/10.2174/187152811798104890)
• Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis. Clinical Biochemistry, Vol. 45. 2012, Issue 6, pp. 429-435.
  Koch A., Zimmermann H.W., Baeck C., Schneider C., Yagmur E., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1016/j.clinbiochem.2012.01.009)
• Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation. Immunity, Vol. 37. 2012, Issue 5, pp. 905-916.
  Seré K., Baek J.H., Ober-Blöbaum J., Müller-Newen G., Tacke F., Yokota Y., Zenke M., Hieronymus T.
  (See online at https://doi.org/10.1016/j.immuni.2012.07.019)
• Frequency and Phenotype of Human Circulating and Intrahepatic Natural Killer Cell Subsets Is Differentially Regulated according to Stage of Chronic Liver Disease. Digestion, Vol.88. 2013, No. 1, pp. 1-16.
  Zimmermann H.W., Mueller J.R., Seidler S., Luedde T., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1159/000350821)
• TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6C(hi) Monocytes during Entamoeba histolytica Infection. PLOS Pathogens, Vol. 9. 2013, Issue 1: e1003096.
  Helk E., Bernin H., Ernst T., Ittrich H., Jacobs T., Heeren J., Tacke F., Tannich E., Lotter H.
  (See online at https://doi.org/10.1371/journal.ppat.1003096)
• Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 10. 2014, Issue 6, pp. 1209-1220.
  Bartneck M., Peters F.M., Warzecha K.T., Bienert M., van Bloois L., Trautwein C., Lammers T., Tacke F.
  (See online at https://doi.org/10.1016/j.nano.2014.02.011)
• Macrophage heterogeneity in liver injury and fibrosis. Journal of Hepatology, Vol. 60. 2014, Issue 5, pp. 1090-1096.
  Tacke F., Zimmermann H.W.
  (See online at https://doi.org/10.1016/j.jhep.2013.12.025)
• Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. Biomaterials, Vol. 37. 2015, pp. 367-382.
  Bartneck M., Scheyda K.M., Warzecha K.T., Rizzo L.Y., Hittatiya K., Luedde T., Storm G., Trautwein C., Lammers T., Tacke F.
  (See online at https://doi.org/10.1016/j.biomaterials.2014.10.030)
• Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology, Vol. 62. 2015, Issue 1, pp. 279-291.
  Heymann F., Peusquens J., Ludwig-Portugall I., Kohlhepp M., Ergen C., Niemietz P., Martin C., van Rooijen N., Ochando J.C., Randolph G.J., Luedde T., Ginhoux F., Kurts C., Trautwein C., Tacke F.
  (See online at https://doi.org/10.1002/hep.27793)