From a genomic atlas to a history book of tumour progression and metastatic outgrowth (A02)

• Subject Area: Hematology, Oncology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 429280966

Tumor progression and metastatic colonization are dynamic processes. Some events happen early in history, others late. Some events can set the stage for colonization of a distant organ, while others such as driver mutations can change the course of a tumor’s history entirely. In the public domain we have an atlas of these events, here we want to compliment it by a history book. We will use our algorithm MHN to annotate mutations by their timing (early/late), by a cancer driver score, and by possible associations with metastasis. To include immunological and clinical events we collaborate with the ongoing PRAEGNANT breast cancer study which generates sequences of up to 850 pairs of primary tumor and metastasis genomes together with immunological characterizations and clinical follow up.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 305: Striking a moving target: From mechanisms of metastatic colonization to novel systemic therapies
• Applicant Institution: Universität Regensburg
• Project Heads: Dr. Lothar Häberle; Professor Dr. Rainer Spang