Target identification across the allele frequency spectrum: from complex to monogenic kidney disease (P15)

• Subject Area: Epidemiology and Medical Biometry/Statistics ; Human Genetics ; Nephrology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

P15 recently discovered common risk variants in >200 novel genetic loci for complex kidney function traits and diseases in >1 million individuals. P15 will address the continuum of genetic risk from complex to monogenic kidney disease by examining the contribution of rare risk alleles in large population-based and CKD patient studies. P15 will use next-generation sequencing approaches to quantify the presence of monogenic kidney disease mutations in adults with presumed complex kidney disease, with the potential to directly inform clinical decisions. The genome-wide results generated by P15 will represent an important resource for other NephGen projects, in which any candidate gene of interest can be investigated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Dr. Matthias Wuttke