Project Details
Discovery and integrated functional genomics of cell-type and compartment-specific kidney disease genes (P16)
Subject Area
Human Genetics
Nephrology
Nephrology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000
Genome-wide studies of kidney function have studied global filtration markers, which integrate effects of different cell types. Most kidney disease risk genes however are important in specific cell types. P16 will therefore perform genetic studies of kidney cell type-specific protein and metabolite biomarkers in large human populations (N = 5,000-500,000), in order to detect new and to characterize known kidney disease risk loci. Implicated genes will be investigated using human kidney cell type-specific chromatin architecture and transcriptome data, and studied for causal associations with kidney disease via tissue-specific transcriptome-based Mendelian Randomization.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1453:
Nephrogenetics (NephGen)
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Head
Professorin Dr. Anna Köttgen