Implications of deregulated proteostasis in cell state transitions (A06)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

Ehrmann aims to uncover the molecular mechanisms of cell cycle checkpoint triggering under conditions of unbalanced proteostasis. This project will address the implications of the widely conserved serine protease HTRA1 in these events. Recent work demonstrates that HTRA1 performs protein quality control and affects cell cycle progression. These studies aim at reveal-ing how HTRA1 senses and modulates proteotoxic stress as well as its implications in the cell cycle and the modulation of checkpoint signalling and activity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1430: Molecular Mechanisms of Cell State Transitions
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Michael Ehrmann