GRK 1123:  Zelluläre Mechanismen von Lernen und Gedächtniskonsolidierung in der hippokampalen Formation

• Fachliche Zuordnung: Neurowissenschaften
• Förderung: Förderung von 2005 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 462239

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Our research training group (RTG) combined innovative approaches in an interdisciplinary fashion to investigate neuronal plasticity as a factor in mechanisms of learning and memory in the hippocampal formation. The hippocampus has long been known to play a key role in the formation of several forms of memory, including episodic and spatial memory. In rodents, hippocampal pyramidal neurons selectively discharge when the animal is in a specific location in space: these neurons are referred to as 'place cells'. Intriguingly, place cells sequentially activated during exploration of space by rodents are subsequently reactivated in the same order during sleep, as if the animal were virtually ‘dreaming’ of the same trajectories. Thus, during exploration a neural assembly is formed which can be reactivated for decision-making and for memory consolidation. This 'replay' occurs during 200 Hz network oscillations known as ‘sharp wave ripples’. The latter, markedly fast timescale is consistent with time windows optimal for induction of long-term potentiation (LTP), the principal candidate as the molecular mechanism of synaptic plasticity underlying memory. Consequently, most studies have focused on synaptic plasticity in the hippocampus, in particular: 1) regulation of transmitter release; 2) mechanisms underlying memory formation and consolidation; 3) homeostatic and heterosynaptic plasticity (and the disturbance of the latter) as a factor in diseases such as temporal lobe epilepsy and Alzheimer’s disease. From the work of the members of the GRK1123 more than 100 papers appeared, many of them in high impact factor journals such as Science, Neuron, and PNAS. A total of 56 funded and associated students were supported by the GRK1123. Approximately 28 students contributed to the success of the second funding period. Many of the GRK1123-funded students found excellent postdoctoral positions in outstanding research groups based at institutions such as Janelia Farm and Cambridge University. The experience of the tutors in the GRK1123 and parallel initiatives led to a successful bid for an Einstein Center, which will be officially publicized in late October 2015. The center will extend the achievements of GRK 1123 by focusing on improved infrastructure for an even more advanced educational platform aimed at a new generation of neuroscientists.

Projektbezogene Publikationen (Auswahl)

• (2007) Synaptic plasticity in the temporal lobe and its alterations in a model of MK-801-induced acute schizophreniform psychosis. FU Berlin
  Wöhrl, R.
  
• (2008) Aggregation, structure and pathological effect of the Amyloid-ß peptide. FU Berlin
  Harmeier, A.
  
• (2008) Changing the copy number of transmitter transporters per vesicle - sorting versus expression under regime of day-night cycle. FU Berlin
  Darna, M
  
• (2008) Disruption of dendritic Arc/Arg3.1-translation impairs a unique intermediate phase of hippocampus-dependent memory. FU Berlin
  Mao, Xiaosong
  
• (2008) The effect of C-type natriuretic peptide on metaplasticity in the hippocampus. FU Berlin
  Decker, JM
  
• A novel control software that improves the experimental workflow of scanning photostimulation experiments. 2008, J Neurosci Methods. 175(1):44-57
  Bendels MH, Beed P, Leibold C, Schmitz D, Johenning FW
  
• C-Type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro. 2008, Biochem. Biophys Res Commun. 19;377(3):820-5
  Decker JM, Wojtowicz A, Heinemann U, Braunewell KH
  
• Conformational switch of syntaxin-1 controls synaptic vesicle fusion. 2008, Science. 321(5895):1507-10
  Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC
  
• Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. 2008, FASEB J. 22(10):3736-46
  Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G
  
• Different motifs regulate trafficking of SorCS1 isoforms. 2008, Traffic, 9(6): 980-94
  Nielsen MS, Keat SJ, Hamati JW, Madsen P, Gutzmann JJ, Engelsberg A, Pedersen KM, Gustafsen C, Nykjaer A, Gliemann J, Hermans-Borgmeyer I, Kuhl D, Petersen CM, Hermey G
  
• (2009) Expression of tumour invasion suppressor gene Visininlike Protein 1 (VILIP-1) and its role in metastasis of squamous cell carcinoma. FU Berlin
  Schönrath née Boeck, K.
  
• (2009) Synaptophysin/Synaptobrevin complex: Characterisation of the Ca2+- dependent cytosolic dissociation of the complex. FU Berlin
  Afube, T.
  
• C-type natriuretic peptide decreases hippocampal network oscillations in adult rats in vitro. 2009, Neuroscience. 164(4):1764-75
  Decker JM, Wójtowicz AM, Ul Haq R, Braunewell KH, Heinemann U, Behrens CJ
  
• Ca2+-dependent regulator of proteins secretion directly promote vesicular monoamine uptake. 2009, J Biol Chem 284:1050- 1056
  Brunk I, Blex C, Speidel D, Brose N, Ahnert-Hilger G
  
• Dendritic compartment and neuronal output mode determine pathway-specific long-term potentiation in the piriform cortex. 2009 Oct 28, J Neurosci.;29(43):13649-61
  Johenning FW, Beed PS, Trimbuch T, Bendels MH, Winterer J, Schmitz D
  
• GluK2-mediated excitability within the superficial layers of the entorhinal cortex. 2009, PLoS One. ;4(5):e5576
  Beed PS, Salmen B, Schmitz D
  
• p53 regulates the self-renewal and differentiation of neural precursors. 2009 Neuroscience.;158(4):1378-89
  Armesilla-Diaz A, Bragado P, Del Valle I, Cuevas E, Lazaro I, Martin C, Cigudosa JC, Silva A
  
• Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity. 2009, J Neurosci. 10;29(23):7582-90
  Harmeier A, Wozny C, Rost BR, Munter LM, Hua H, Georgiev O, Beyermann M, Hildebrand PW, Weise C, Schaffner W, Schmitz D, Multhaup G
  
• Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. 2009 Sep 18, Cell.;138(6):1222-35
  Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Bräuer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R
  
• The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. 2009 Dec;11, Nat Cell Biol. (12):1411-20
  Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG
  
• Time- of-day-dependent sorting of vesicular glutamate transporter to the plasma membrane. 2009, J Biol Chem 284:4300-4307
  Darna M, Schmutz I , Richter K, Höltje M, Yelamanchili SV, Pendyala G, Albrecht U, Ahnert-Hilger G
  
• (2010) Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. 2010, J Biol Chem. ;285(53):41517-24
  Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L, Bayer TA
  
• (2010) Loss of long-term potentiation at the CA1-subiculum synapse in temporal lobe epilepsy. FU Berlin
  Buck, N.
  
• (2010) Microcircuitry in the entorhinal cortex. FU Berlin
  Beed, P.
  
• (2010) Regulation of synaptic vesicle membrane trafficking events at neuronal synapses; FU Berlin (Dissertation)
  Pechstein, A.
  
• (2010) The reaction of spatial active hippocampal CA1-Pyramidal neurons to an exposition into a novel environment and their modulation during sleep. FU Berlin
  Lüdert, T.
  
• Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization. 2010, J Neurochem. 115(1):234-46
  Brunk I, Sanchis-Segura C, Blex C, Perreau-Lenz S, Bilbao A, Spanagel R, Ahnert-Hilger G
  
• C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro. 2010, Neuroscience.169(1):8-22
  Decker JM, Wójtowicz AM, Bartsch JC, Liotta A, Braunewell KH, Heinemann U, Behrens CJ
  
• Detection of input sites in scanning photostimulation data based on spatial correlations. 2010, J Neurosci Methods. 192(2):286-95
  Bendels MH, Beed P, Schmitz D, Johenning FW, Leibold C
  
• Intersectin 1: a versatile actor in the synaptic vesicle cycle. 2010 , Biochemical Society transactions 38:181-186
  Pechstein A, Shupliakov O, Haucke V
  
• MiRNA need a TRIM regulation of miRNA activity by Trim-NHL proteins. 2010, Adv Exp Med Biol. 2010;70
  Wulczyn FG, Cuevas E, Franzoni E, Rybak A
  
• Molecular basis for SH3 domain regulation of F-BAR- mediated membrane deformation. 2010, Proceedings of the National Academy of Sciences of the United States of America 107:8213-8218
  Rao Y, Ma Q, Vahedi-Faridi A, Sundborger A, Pechstein A, Puchkov D, Luo L, Shupliakov O, Saenger W, Haucke V
  
• Neuroligin 1 is dynamically exchanged at postsynaptic sites. 2010, J Neurosci 30:12733–12744
  Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SGN, Schweizer M, Schmitz D, Schwarz JR, Holzbaur ELF, Kneussel M
  
• Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. 2010, J Neural Transm (Vienna). 117(1):85-96
  Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA
  
• Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. 2010, Proceedings of the National Academy of Sciences of the United States of America 107:4206-4211
  Pechstein A, Bacetic J, Vahedi-Faridi A, Gromova K, Sundborger A, Tomlin N, Krainer G, Vorontsova O, Schafer JG, Owe SG, Cousin MA, Saenger W, Shupliakov O, Haucke V
  
• Synaptic and vesicular co-existence of VGLUT and VGAT in selected excitatory and inhibitory synapses. 2010, J Neurosci 30:7634-7645
  Zander JF, Münster-Wandowski A, Brunk I, Pahner I, Gómez-Lira G, Heinemann U, Gutiérrez R, Laube G, Ahnert-Hilger G
  
• (2011) Analysis of the influence of the amyloid-β 42 peptide on gene regulation. FU Berlin
  Barucker, C.
  
• (2011) Gemeinsames Vorkommen von VGLUT und VGAT auf synaptischen Vesikeln und in inhibitorischen und exzitatorischen Nervenendigungen; HU-Berlin
  Zander, JF
  
• (2011) LPA signalling during axon growth
  Soriguera Farés, A.
  
• (2011) Neurotoxic phospholipases directly affect synaptic vesicle function. J Neurochem 117:757-764
  Treppmann P, Brunk I, Afube T, Richter K, Ahnert-Hilger G
  
• (2011) Target-cell-specific bidirectional synaptic plasticity at the CA1-subiculum synapse. FU Berlin
  Shor, O
  
• (2011) The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. 2011, EMBO J. 30(10):2057-70
  Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J
  
• (2011) Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. Biol Chem. 392(10):919-26
  Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G, Schaffner W
  
• (2011): Action potentials in primary osteoblasts and osteoblast like cell line MG-63. 2011 Jun , J Bioenerg Biomembr.;43(3):311-22
  Pangalos M, Bintig W, Schlingmann B, Feyerabend F, Witte F, Begandt D, Heisterkamp A, Ngezahayo A
  
• Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus. 2011, J Neurosci 30(38):8464–8475
  Winterer J, Stempel AV, Dugladze T, Földy C, Maziashvili N, Zivkovic AR, Priller J, Soltesz I, Gloveli T, Schmitz D
  
• Coherent phasic excitation during hippocampal ripples. 2011, Neuron. 72(1):137-52
  Maier N, Tejero-Cantero A, Dorrn AL, Winterer J, Beed PS, Morris G, Kempter R, Poulet JF, Leibold C, Schmitz D
  
• Complementary sensory and associative microcircuitry in primary olfactory cortex. 2011 Aug 24, J Neurosci.;31(34):12149-58
  Wiegand HF, Beed P, Bendels MH, Leibold C, Schmitz D, Johenning FW
  
• Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus. 2011 Aug 3, Neuroreport.;22(11):520-4
  Fano S, Çalışkan G, Behrens CJ, Heinemann U
  
• Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus. 2011 Aug 3, Neuroreport.;22(11):520-4
  Fano S, Çalışkan G, Behrens CJ, Heinemann U
  
• How synapsin I may cluster synaptic vesicles. 2011, Seminars in cell & developmental biology 22:393-399
  Shupliakov O, Haucke V, Pechstein A
  
• miRNAs Need a Trim: Regulation of miRNA Activity by Trim-NHL Proteins. 2011 AdvExpMedBiol 700:85–105
  Wulczyn FG, Cuevas E, Franzoni E, Rybak A
  
• Nonspecific effects of the gap junction blocker mefloquine on fast hippocampal network oscillations in the adult rat in vitro. 2011, Neuroscience. 192:11-9
  Behrens CJ, ul Haq R, Liotta A, Anderson ML, Heinemann U
  
• Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices. 2011 Jan, J Neurophysiol.;105(1):172-87
  Liotta A, Caliskan G, ul Haq R, Hollnagel JO, Rösler A, Heinemann U, Behrens CJ
  
• RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. 2011 Dec 16, Science;334(6062):1565-9
  Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ
  
• RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. 2011, Dec 16. Science. 2011 Dec 16;334(6062):1565-9
  Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ
  
• Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell. 2011 Aug 5;146(3):471-84. Erratum in: Cell.;146(5):841. Tomlin, Nikolay [corrected to Tomilin, Nikolay]
  von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, MacGregor KA, Tomilin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V
  
• (2012) Impact of disinhibition and neuromodulation in hippocampal oscillations and LTP. FU Berlin
  Liotta, A.
  
• (2012) Modulation of hippocampal sharp wave-ripple activity in vitro. FU Berlin
  ul Haq, R.
  
• (2012) Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers. EMBO Mol Med. (7):647-59
  Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G
  
• (2012): From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. 2012 Jun, Ann N Y Acad Sci.;1257:142-51
  Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM
  
• (2012): Purinergic receptors and Ca2+ signalling in the human blood-brain barrier endothelial cell line hCMEC/D3. 2012 Mar;8, Purinergic Signal. (1):71-80
  Bintig W, Begandt D, Schlingmann B, Gerhard L, Pangalos M, Dreyer L, Hohnjec N, Couraud JP, Romera AI, Weksler B, Ngezahayo A
  
• 20 years later: A second look on DF's motor behavior. 2012, Neuropsychologia 50(1):139-44
  Himmelbach M, Boehme R, Karnath HO
  
• Adrenergic modulation of sharp wave-ripple activity in rat hippocampal slices.Hippocampus. 2012 Mar;22(3):516-33
  ul Haq R, Liotta A, Kovacs R, Rösler A, Jarosch MJ, Heinemann U, Behrens CJ
  
• All layers of medial entorhinal cortex receive presubicular and parasubicular inputs. 2012 Dec 5, J Neurosci.;32(49):17620-31
  Canto CB, Koganezawa N, Beed P, Moser EI, Witter MP
  
• An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. 2012, Nat Neurosci 15:827–835
  Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S
  
• Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. 2012, Nature 486(7402):256-60
  Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV et al.
  
• Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices. 2012 Dec, Eur J Neurosci., (12):3628-35
  Fano S, Çalışkan G, Heinemann U
  
• Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices. 2012 Dec, Eur J Neurosci., (12):3628-35
  Fano S, Çalışkan G, Heinemann U
  
• Energy demand of synaptic transmission at the hippocampal Schaffercollateral synapse. 2012 Nov, J Cereb Blood Flow Metab. 32(11):2076-83
  Liotta A, Rösner J, Huchzermeyer C, Wojtowicz A, Kann O, Schmitz D, Heinemann U, Kovács R
  
• Expression of toll-like receptors in the developing brain. 2012, PLoS ONE 7:e37767
  Kaul D, Habbel P, Derkow K, Krüger C, Franzoni E, Wulczyn FG, Bereswill S, Nitsch R, Schott E, Veh R et al.
  
• Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1 receptors in naive and chronic epileptic rats. 2012 Nov, Epilepsia.;53(11):1978-86
  Klaft ZJ, Schulz SB, Maslarova A, Gabriel S, Heinemann U, Gerevich Z
  
• Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7. 2012 Aug 1, J Immunol.;189(3):1448-58
  Lehmann SM, Rosenberger K, Krüger C, Habbel P, Derkow K, Kaul D, Rybak A, Brandt C, Schott E, Wulczyn FG, Lehnardt S
  
• First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. . 2012 Dec, Br J Pharmacol ;167(7):1480-91
  Schulz SB, Heidmann KE, Mike A, Klaft ZJ, Heinemann U, Gerevich Z
  
• Grid cells in rat entorhinal cortex encode physical space with independent firing fields and phase precession at the single-trial level. 2012 Apr 17, Proc Natl Acad Sci USA.;109(16):6301-6
  Reifenstein ET, Kempter R, Schreiber S, Stemmler MB, Herz AV
  
• Light-controlled toxicity of engineered amyloid β-peptides. 2012 Dec 21, Chembiochem;13(18):2657-60
  Hoppmann C, Barucker C, Lorenz D, Multhaup G, Beyermann M
  
• Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges. 2012 Dec., Neurobiol Dis. 48(3):495-506
  Lapilover EG, Lippmann K, Salar S, Maslarova A, Dreier JP, Heinemann U, Friedman A
  
• Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations. 2012 Feb, Neuropharmacology.;62(2):914-24
  Schulz SB, Klaft ZJ, Rösler AR, Heinemann U, Gerevich Z
  
• Reduced ictogenic potential of 4- aminopyridine in the hippocampal region in the pilocarpine model of epilepsy. 2012 Apr 4, Neurosci Lett.;513(2):124-8
  Zahn RK, Liotta A, Kim S, Sandow N, Heinemann U
  
• (2013) Bruchpilot and RIM-binding protein determine presynaptic release; FU- Berlin
  Knoche, E.
  
• (2013) Characterization of Tmem128 – An activity regulated ER protein, interacting with the immediate early gene Arc/Arg3.1. FU Berlin
  Gutzmann, JJ
  
• (2013) Histaminergic modulation of gamma oscillations in rat hippocampus Histaminergene Modulation von Gammaoszillationen im Hippocampus einer Ratte. FU Berlin
  Fano, S
  
• A LED-based method for monitoring NAD(P)H and FAD fluorescence in cell cultures and brain slices. 2013 Jan 30, J Neurosci Methods.;212(2):222-7
  Rösner J, Liotta A, Schmitz D, Heinemann U, Kovács R
  
• Fast neurotransmitter release regulated by the endocytic scaffold intersectin. 2013, Proceedings of the National Academy of Sciences of the United States of America 110:8266-8271
  Sakaba T, Kononenko NL, Bacetic J, Pechstein A, Schmoranzer J, Yao L, Barth H, Shupliakov O, Kobler O, Aktories K, Haucke V
  
• Genome-wide profiling of the activity-dependent hippocampal transcriptome. 2013 Oct 17, PLoS One.;8(10):e76903
  Hermey G, Mahlke C, Gutzmann JJ, Schreiber J, Blüthgen N, Kuhl D
  
• Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex. 2013 Sep 18, Neuron.;79(6):1197-207
  Beed P, Gundlfinger A, Schneiderbauer S, Song J, Böhm C, Burgalossi A, Brecht M, Vida I, Schmitz D
  
• Long-lasting increase of corticosterone after fear memory reactivation: anxiolytic effects and network activity modulation in the ventral hippocampus. 2013 Feb, Neuropsychopharmacology. (;38(3):386-94
  Albrecht A, Çalışkan G, Oitzl MS, Heinemann U, Stork O
  
• Model peptides uncover the role of the β-secretase transmembrane sequence in metal-ion mediated oligomerization. 2013 Dec 26. J Am Chem Soc. ;135(51):19354-61
  Munter LM, Sieg H, Bethge T, Liebsch F, Bierkandt FS, Schleeger M, Bittner HJ, Heberle J, Jakubowski N, Hildebrand PW, Multhaup G
  
• Noradrenergic interactions via autonomic nervous system: a promising target for extinction-based exposure therapy? 2013 Dec, J Neurophysiol.;110(11):2507-10
  Calişkan G, Albrecht A
  
• Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples. 2013, Proc Natl Acad Sci USA 110(11):4398-403
  Pangalos M, Donoso JR, Winterer J, Zivkovic AR, Kempter R, Maier N, Schmitz D
  
• Reinforcement learning and dopamine in schizophrenia: dimensions of symptoms or specific features of a disease group? 2013, Frontiers in Psychiatry 4:172
  Deserno L, Boehme R, Heinz A, Schlagenhauf F
  
• Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. 2013 Oct;16 (Nat Neurosci. 10):1453-60
  Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ
  
• Synaptic requiem: a duet for Piccolo and Bassoon. 2013 Apr 3, EMBO J.;32(7):920-2
  Kononenko N, Pechstein A, Haucke V
  
• Synaptophysin is involved in resetting of the mammalian circadian clock. 2013 Oct 1, J Circadian Rhythms.;11(1):11
  Aramendy M, Seibert S, Treppmann P, Richter K, Ahnert-Hilger G, Albrecht U
  
• The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. 2013 Aug 19, J Cell Biol;202(4):667-83
  Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ
  
• The tortoise and the hare revisited. 2013 Sep 3, Elife.;2:e01233. doi: 10.7554/eLife.01233
  Kononenko NL, Pechstein A, Haucke V
  
• The α-subunit of the trimeric GTPase Go2 regulates axonal growth. 2013, J Neurochem 124:782-794
  Baron J, Blex C, Rohrbeck A, Rachakonda SK, Birnbaumer L, Ahnert-Hilger G, Brunk I
  
• Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability. 2013. J Neurosci 133:16698-16714
  Arancillo, M., Min, S.W., Gerber, S., Münster-Wandowski, A., Wu, Y.J., Herman, M., Trimbuch, T., Rah, J.C., Ahnert-Hilger, G., Riedel, D., Südhof, T.C., Rosenmund, C.
  
• uevas Garcia, E., (2013) Study of the murine Stem Cell E3 Ubiquitin ligase Lin41 in Development and Postnatal stages through the characterization of Lin41 Gene Trap and conditional Knockout models. FU Berlin
  Cuevas Garcia, E.
  
• (2014) Contribution of intrinsic properties of neurons on network oscillations in the rat hippocampus. FU Berlin
  Kunert, A.
  
• (2014) miR-128: a pleiotropic regulator of neuronal translation. FU Berlin
  Franzoni, E
  
• (2014) miR-128: a pleiotropic regulator of neuronal translation. FU Berlin
  Franzoni, E
  
• 2014 The two-neuron microcircuit: an in vitro model for studying synapse formation and function. FU Berlin
  Chang, Chia-Ling
  
• A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. 2014 Jun 12, Cell Rep;7(5):1417-25
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• Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures. 2014 Aug, Epilepsia.;55(8):1255-63
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