Targeting and immunomodulator structures and their coupling to therapeutic nanosystems for onco-logical application (Q05*)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

The new project Q5 will further evolve the existing nanocarrier systems within the CRC through new chemical ligation methods and selective targeting structures. For an effective targeting of immune cells, e.g. saccha-ridic recognition sequences (oligosaccharides) will be attached to the nanocarriers through responsive linker systems. As a practical application of newly developed targeting structures and their conjugation chemistry, inhibitors of the cysteine-cathepsin S, an important regulator of antigen presentation, will be conjugated to nanoparticles or used as a non-covalent payload. The resulting constructs will be evaluated as potential tumor therapeutics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Till Opatz; Professorin Dr. Tanja Schirmeister; Professorin Dr. Tanja Weil