From nanomaterial surface to function - multifunctional PEGylation, targeting and in vivo proteomics (Q06*)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

The work of TP Q6 will focus on the analysis of protein corona and the biodistribution of nanomaterials after systemic application. Extending the work of previous TP B11 and TP A7, the composition and relevance of the protein corona for blood circulation and the targeting of NP will be analyzed. In particular, the im-portance of different antibody formats (whole antibody, Fab fragments, scFv, nanobodies) and their suitabil-ity for targeting efficiency will be further explored. Furthermore, the effects of different surface modifica-tions (chemical variation of polyether architectures and functionality) on protein corona and in vivo targeting by surface functionalization (Fab antibody fragments, nanobodies) will be investigated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Holger Frey; Professor Dr. Volker Mailänder; Professor Dr. Stefan Tenzer